Activated folate & activated B vitamins with choline; advanced methylation neurological & cardiovascular support
Premier Research Labs’ Phyto-Methylate delivers the most dynamic support in methyl group supplementation for human nutrition today. Phyto-Methylate is a rich source of biologically available methyl do-nors and cofactors important for advanced cellular functions such as DNA methylation, homocysteine synthesis and protein synthesis. Phyto-Methylate directly delivers advanced methylation through the fully activated methyl donors of folate as 5-methyltetrahydro-folate, B12 as methylcobalamin, B6 as pyridoxal-5-phosphate and choline bitartrate.
Methylation is the biochemical process of the transfer of one car-bon atom and three hydrogen atoms, CH3 – a methyl group, from one substance to another. Supporting healthy methylation is vital to promoting healthy genetic expression and cellular functions. When sufficient methyl groups are available, it has a positive effect regu-lating many biochemical reactions throughout the body including car-diovascular, neurological, reproductive and detoxification systems.
Through a series of biochemical reactions with homocysteine, the coenzyme factors of vitamin B12 and folate are critical to the methionine synthase pathway, supporting healthy homo-cysteine metabolism and S-adenosylmethionine (SAMe) pro-duction. This methylation cycle only works if enough folate (5-MTHF) and B-12 as methylcobalimin are present.
It is suggested that 60% of the population suffers from a ge-netic mutation compromising the proper conversion of un-methylated vitamin Bs. Without proper methyl transfer for homocysteine modulation, the necessary formation of methyl donors involved in cardiovascular, neurological, reproductive and detoxification functions cannot be adequately produced.
Premier Research Labs’ Phyto-Methylate contains thee fully active co-enzymes of the blood-circulating forms of folate (as 5-methytetrahydrofolate), vitamin B12 (as methylcobalamin) and B6 (as pyridoxal-5-phosphate). While the body is able to absorb food-source vitamin Bs, it must further convert them to these three coenzyme forms in order for it to become met-abolically active in the body.
Unfortunately, over half of the U.S. population is unable to metabolize the unmethylated forms of specific B vitamins, namely folate and vitamin B12. When folate (as 5-methyltet-rahydrofolate) and vitamin B12 (as methylcobalamin) are pro-vided to the body in these active biologically forms, they are able to yield optimal bioavailability as well as tissue reten-tion which can promote healthy methyl formation.
The enzyme, methylene tetrahydrofolate reductase (MTHFR), catalyzes the first steps of the biosynthesis of sulfur-contain-ing amino acids, including that of methionine via homocyste-ine. Vitamin B12 (preferably methylcobalamin) is a cofactor for methionine synthase, the enzyme which directly catalyzes this conversion. These relationships are important to acknowl-edge, as fluctuations in bioavailable B vitamins can shift the dynamics of reactions requiring free choline as well. Choline intake has also been shown to have a direct inverse effect on levels of plasma homocysteine by working in synergy with end-chain B vitamins in homocysteine metabolism because of their shared roles in methylation and amino acid synthesis.
Choline substantially contributes to the pool of methyl groups that can be used for one-carbon transfer reactions with DNA and protein. Choline is oxidized in a two-step process and subse-quently remethylates homocysteine to S-adenosylmethionine, a methyl donor necessary for the synthesis of DNA and RNA, the myelin insulation for neurons and other biological materials.
2 Capsules Provide:
Choline (from grape fermentation as Choline Bitartrate) . . . . 110 mg
Vitamin B6 (including Pyrdoxal-5-Phosphate) . . . . . . . . . . . . . . 25 mg
Vitamin B12 (Methylocbalamin) . . . . . . . . . . . . . . . . . . . . . . 1000 mcg
Folate (as 5-Methyltetrahydrofolate) . . . . . . . . . . . . . . . . . . . 400 mcg
Green Methyl Support . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 558 mg
Organic Rice Concentrate (Oryza sativa), Organic Barley (leaf) (Hordeum vulgare),
Organic Oat Grass (Avenea sativa), Organic Parsley (leaf) (Petroselinum crispum)
Other Ingredients: Vegetable Capsules (hydroxypropyl methyl cellulose)
Meets Our Bioresonance Criteria 
No Added Stearates 
Organic Ingredient (1 or more) 
Plant-Source Capsules 
Pure Vegan 
Violite Bottle Take 2 capsules daily or as directed by a health professional.
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